If you're using multiple mouses with your Apple as I am (work and home), it might annoy you that the mouse speeds are different for each mouse. To mitigate these problems to some extent, you can use Steermouse to configure your mouse and then use the Applescript snippet on their website to make shortcuts for your specific mouse settings in an Applescript file.

Currently I'm using the following settings:

tell application "SteerMouse"
  set text "cursor tracking speed" to 0.025
  set text "cursor sensitivity" to 800
end tell

Related info: